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GPCR

NameD(2) dopamine receptor
SpeciesMus musculus (Mouse)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61168
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3427
IUPHAR215
DrugBankN/A

Ligand

NameCHEMBL335327
Molecular formulaC16H22FNO
IUPAC name1-(cyclopropylmethyl)-4-[(4-fluorophenoxy)methyl]piperidine
Molecular weight263.356
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP3.5
Synonyms1-Cyclopropylmethyl-4-(4-fluoro-phenoxymethyl)-piperidine
SCHEMBL7362469
BDBM50002207
1-(Cyclopropylmethyl)-4-(4'-Fluorophenoxymethyl) piperidine
GXKBHNBKDZPNIG-UHFFFAOYSA-N
[ Show all ]
Inchi KeyGXKBHNBKDZPNIG-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H22FNO/c17-15-3-5-16(6-4-15)19-12-14-7-9-18(10-8-14)11-13-1-2-13/h3-6,13-14H,1-2,7-12H2
PubChem CID10015631
ChEMBLCHEMBL335327
IUPHARN/A
BindingDB50002207
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50381.0 nMPMID1360026BindingDB,ChEMBL

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