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GPCR

NameHistamine H4 receptor
SpeciesMus musculus (Mouse)
GeneHrh4
SynonymGPCR105
H4 receptor
H4R
HH4R
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
UniProtQ91ZY2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5657
IUPHAR265
DrugBankN/A

Ligand

NameJMC516547 Compound 5
Molecular formulaC15H16N6
IUPAC name4-(2-amino-6-piperazin-1-ylpyrimidin-4-yl)benzonitrile
Molecular weight280.335
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP1.0
SynonymsSCHEMBL2166460
4-[2-amino-6-(piperazin-1-yl)pyrimidin-4-yl]benzonitrile
CHEMBL494890
2-Aminopyrimidine analog., 25
BDBM26230
Inchi KeyGXPQVRIHPFBPOG-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H16N6/c16-10-11-1-3-12(4-2-11)13-9-14(20-15(17)19-13)21-7-5-18-6-8-21/h1-4,9,18H,5-8H2,(H2,17,19,20)
PubChem CID25130576
ChEMBLCHEMBL494890
IUPHARN/A
BindingDB26230
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50102.33 nMPMID18817367, PMID18811133ChEMBL
Efficacy53.0 %PMID18811133ChEMBL
Efficacy54.0 %PMID18817367ChEMBL

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