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Name | Histamine H4 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH4 |
Synonym | Pfi-013 SP9144 HH4R H4R H4 receptor [ Show all ] |
Disease | Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis |
Length | 390 |
Amino acid sequence | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS |
UniProt | Q9H3N8 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9H3N8 |
3D structure model | This predicted structure model is from GPCR-EXP Q9H3N8. |
BioLiP | N/A |
Therapeutic Target Database | T26500 |
ChEMBL | CHEMBL3759 |
IUPHAR | 265 |
DrugBank | BE0000146 |
Name | CHEMBL492677 |
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Molecular formula | C16H22N6 |
IUPAC name | 4-N-benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine |
Molecular weight | 298.394 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 1.9 |
Synonyms | BDBM50304527 N4-Benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine SCHEMBL2166970 |
Inchi Key | GXRZHULPUGZJMQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H22N6/c1-21-7-9-22(10-8-21)15-11-14(19-16(17)20-15)18-12-13-5-3-2-4-6-13/h2-6,11H,7-10,12H2,1H3,(H3,17,18,19,20) |
PubChem CID | 25130914 |
ChEMBL | CHEMBL492677 |
IUPHAR | N/A |
BindingDB | 50304527 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 21.38 nM | PMID19773175 | ChEMBL |
EC50 | 64.57 nM | PMID18811133 | ChEMBL |
Efficacy | 56.0 % | PMID18811133 | ChEMBL |
Emax | 34.5 % | PMID19773175 | ChEMBL |
Ki | 20.0 nM | PMID21458260 | BindingDB,ChEMBL |
Ki | 98.0 nM | PMID19773175 | BindingDB,ChEMBL |
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