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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	CHEMBL115710
Molecular formula	C28H36F2N2O3
IUPAC name	4-[2-[2-[3-[bis(4-fluorophenyl)methoxy]-8-azabicyclo[3.2.1]octan-8-yl]ethoxy]ethyl]morpholine
Molecular weight	486.604
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	4.2
Synonyms	BDBM50148734 3-[Bis-(4-fluoro-phenyl)-methoxy]-8-[2-(2-morpholin-4-yl-ethoxy)-ethyl]-8-aza-bicyclo[3.2.1]octane
Inchi Key	ABQQJUQDHRDZGR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H36F2N2O3/c29-23-5-1-21(2-6-23)28(22-3-7-24(30)8-4-22)35-27-19-25-9-10-26(20-27)32(25)14-18-34-17-13-31-11-15-33-16-12-31/h1-8,25-28H,9-20H2
PubChem CID	44342206
ChEMBL	CHEMBL115710
IUPHAR	N/A
BindingDB	50148734
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	15800.0 nM	PMID15189035	BindingDB,ChEMBL

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