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Name | Vasopressin V1a receptor |
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Species | Homo sapiens (Human) |
Gene | AVPR1A |
Synonym | AVPR V1a AVPR Antidiuretic hormone receptor 1a AVPR1 V1A receptor [ Show all ] |
Disease | Euvolemic hyponatremia Hyponatraemia Dysmenorrhea Cardiotonic Infertility [ Show all ] |
Length | 418 |
Amino acid sequence | MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST |
UniProt | P37288 |
Protein Data Bank | N/A |
GPCR-HGmod model | P37288 |
3D structure model | This predicted structure model is from GPCR-EXP P37288. |
BioLiP | N/A |
Therapeutic Target Database | T79232 |
ChEMBL | CHEMBL1889 |
IUPHAR | 366 |
DrugBank | BE0000165 |
Name | Tolvaptan |
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Molecular formula | C26H25ClN2O3 |
IUPAC name | N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide |
Molecular weight | 448.947 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 2 |
XlogP | 4.8 |
Synonyms | 4CA-1265 AB01565822_02 ANW-59865 C26H25ClN2O3 D03KZM [ Show all ] |
Inchi Key | GYHCTFXIZSNGJT-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31) |
PubChem CID | 216237 |
ChEMBL | CHEMBL344159 |
IUPHAR | 2226 |
BindingDB | 35723 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 580.0 nM | PMID10482466 | BindingDB |
Ki | 12.3 nM | PMID9864265 | PDSP,BindingDB |
Ki | 12.5893 nM | PMID9864265 | IUPHAR |
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