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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesRattus norvegicus (Rat)
GeneHtr1a
Synonym5-HT1A receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
5-HT1A
ADRB2RL1
ADRBRL1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length422
Amino acid sequenceMDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProtP19327
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL273
IUPHAR1
DrugBankN/A

Ligand

NameCHEMBL358474
Molecular formulaC19H22FNO
IUPAC name3-[(4-fluorophenyl)-(4-methylphenoxy)methyl]piperidine
Molecular weight299.389
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.2
SynonymsBDBM50136161
SCHEMBL12156352
3-[(4-Fluoro-phenyl)-p-tolyloxy-methyl]-piperidine
Inchi KeyAPDAFEORIXULGY-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H22FNO/c1-14-4-10-18(11-5-14)22-19(16-3-2-12-21-13-16)15-6-8-17(20)9-7-15/h4-11,16,19,21H,2-3,12-13H2,1H3
PubChem CID11174064
ChEMBLCHEMBL358474
IUPHARN/A
BindingDB50136161
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<1000.0 nMPMID14640559BindingDB,ChEMBL

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