You can:
Name | Alpha-1D adrenergic receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Adra1d |
Synonym | ADRA1A Gpcr8 Adra-1 alpha1D-AR alpha1D-adrenoceptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 561 |
Amino acid sequence | MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI |
UniProt | P23944 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL326 |
IUPHAR | 24 |
DrugBank | N/A |
Name | WB-4101 |
---|---|
Molecular formula | C19H23NO5 |
IUPAC name | N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine |
Molecular weight | 345.395 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 2.9 |
Synonyms | 2170-58-3 (hydrochloride) BRD-A01493904-003-02-2 D03QMR KBioGR_001646 N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine [ Show all ] |
Inchi Key | GYSZUJHYXCZAKI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3 |
PubChem CID | 5685 |
ChEMBL | CHEMBL25554 |
IUPHAR | 499 |
BindingDB | 69602 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 1.58 nM | PMID11931617 | BindingDB |
Kd | 1.585 nM | PMID11931617, PMID16216506 | ChEMBL |
Kd | 2.51 nM | PMID12672251 | BindingDB |
Kd | 2.512 nM | PMID17125266, PMID12672251 | ChEMBL |
Ki | 1.2 nM | PMID7658428 | BindingDB,ChEMBL |
Ki | 6.26 nM | PMID8667368 | BindingDB,ChEMBL |
pKb | 8.6 - | PMID10514291, PMID10425105 | ChEMBL |
pKb | 8.8 - | PMID18817363, PMID20801662 | ChEMBL |
pKB | 8.85 - | PMID14584940 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218