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GPCR

NameEndothelin receptor type B
SpeciesHomo sapiens (Human)
GeneEDNRB
SynonymETB receptor
ET-B
Endothelin receptor non-selective type
HSCR2
endothelin B receptor
[ Show all ]
DiseaseArrhythmia
Cancer
Cardiovascular disorder
Hypertension
Solid tumours
[ Show all ]
Length442
Amino acid sequenceMQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
UniProtP24530
Protein Data Bank5xpr, 6igl, 5x93, 6igk
GPCR-HGmod modelP24530
3D structure modelThis structure is from PDB ID 5xpr.
BioLiPBL0388896, BL0388813, BL0433639, BL0433638, BL0388814
Therapeutic Target DatabaseT92828
ChEMBLCHEMBL1785
IUPHAR220
DrugBankBE0000043

Ligand

NameCHEMBL294095
Molecular formulaC14H13FN2O4S
IUPAC name6-ethylsulfonyl-N-(4-fluorophenyl)-1-oxidopyridin-1-ium-3-carboxamide
Molecular weight324.326
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP0.7
SynonymsSCHEMBL3218773
BDBM50102216
6-Ethanesulfonyl-N-(4-fluoro-phenyl)-1-oxy-nicotinamide
2-(Ethylsulfonyl)-5-(4-fluorophenylaminocarbonyl)pyridine 1-oxide
Inchi KeyGYTDPDSEJRDDCB-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H13FN2O4S/c1-2-22(20,21)13-8-3-10(9-17(13)19)14(18)16-12-6-4-11(15)5-7-12/h3-9H,2H2,1H3,(H,16,18)
PubChem CID9967031
ChEMBLCHEMBL294095
IUPHARN/A
BindingDB50102216
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition15.0 %PMID11459668ChEMBL

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