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GPCR

NameKappa-type opioid receptor
SpeciesCavia porcellus (Guinea pig)
GeneOPRK1
SynonymKOR-1
K-OR-1
DiseaseN/A for non-human GPCRs
Length380
Amino acid sequenceMGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
UniProtP41144
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3952
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1162502
Molecular formulaC24H39N3
IUPAC name(3S,6S)-7-[2-(1-adamantyl)ethyl]-6-cyclohexyl-3-methyl-2,3,5,6-tetrahydroimidazo[1,2-a]imidazole
Molecular weight369.597
Hydrogen bond acceptor1
Hydrogen bond donor0
XlogP5.9
SynonymsN/A
Inchi KeyABRAIKMFZBEEHN-VMUPYFCGSA-N
Inchi IDInChI=1S/C24H39N3/c1-17-15-25-23-26(22(16-27(17)23)21-5-3-2-4-6-21)8-7-24-12-18-9-19(13-24)11-20(10-18)14-24/h17-22H,2-16H2,1H3/t17-,18?,19?,20?,22+,24?/m0/s1
PubChem CID46905618
ChEMBLCHEMBL1162502
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC501941.0 nMPMID18468907ChEMBL

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