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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesHomo sapiens (Human)
GeneMCHR1
SynonymSLC-1
Somatostatin receptor-like protein
MCHR-1
MCHR
MCH1R
[ Show all ]
DiseaseObesity
Obesity; Anxiety; Depression
Length422
Amino acid sequenceMSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProtQ99705
Protein Data BankN/A
GPCR-HGmod modelQ99705
3D structure modelThis predicted structure model is from GPCR-EXP Q99705.
BioLiPN/A
Therapeutic Target DatabaseT09572
ChEMBLCHEMBL344
IUPHAR280
DrugBankBE0003478

Ligand

NameCHEMBL2017757
Molecular formulaC24H26ClN5O3S
IUPAC name(E)-3-(4-chlorophenyl)-N-[2-[4-(methanesulfonamido)piperidin-1-yl]-4-methylquinazolin-6-yl]prop-2-enamide
Molecular weight500.014
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP3.9
SynonymsBDBM50381527
Inchi KeyAPJHPDHCTJFODM-BJMVGYQFSA-N
Inchi IDInChI=1S/C24H26ClN5O3S/c1-16-21-15-20(27-23(31)10-5-17-3-6-18(25)7-4-17)8-9-22(21)28-24(26-16)30-13-11-19(12-14-30)29-34(2,32)33/h3-10,15,19,29H,11-14H2,1-2H3,(H,27,31)/b10-5+
PubChem CID70687551
ChEMBLCHEMBL2017757
IUPHARN/A
BindingDB50381527
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC5014.0 nMPMID22497763BindingDB,ChEMBL
IC5031.0 nMPMID22497763BindingDB,ChEMBL

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