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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL315836
Molecular formula	C21H15ClFN3
IUPAC name	4-[2-(4-chlorophenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-2-methylpyridine
Molecular weight	363.82
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.1
Synonyms	2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-(2-methyl-4-pyridyl)-1H-imidazole BDBM50104380 4-[2-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-2-methyl-pyridine BDBM50218790
Inchi Key	APKKXGAJMPHCEP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H15ClFN3/c1-13-12-16(10-11-24-13)20-19(14-4-8-18(23)9-5-14)25-21(26-20)15-2-6-17(22)7-3-15/h2-12H,1H3,(H,25,26)
PubChem CID	44319257
ChEMBL	CHEMBL315836
IUPHAR	N/A
BindingDB	50104380
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	50.0 nM	, Med Chem Res, (2013) None:None:1	BindingDB,ChEMBL
Inhibition	38.0 %	PMID11549467	ChEMBL

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