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GPCR

NameMelanocortin receptor 4
SpeciesMus musculus (Mouse)
GeneMc4r
SynonymMC4 receptor
MC4-R
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY
UniProtP56450
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3719
IUPHARN/A
DrugBankN/A

Ligand

NameCID 102096776
Molecular formulaC71H90N20O15S3
IUPAC name(2S,5S,8S,11S,14R,19R,22S,25S,28S,34S)-19-[[(2S)-2-amino-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino]-11-benzyl-34-(3-carbamimidamidopropyl)-3,6,9,12,20,23,26,36-octahydroxy-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-iminopropan-2-yl]-5-(2-hydroxy-2-iminoethyl)-22-(1H-imidazol-5-ylmethyl)-2-(1H-indol-3-ylmethyl)-8,25-dimethyl-32-oxo-16,17,30-trithia-1,4,7,10,13,21,24,27,35-nonazabicyclo[26.4.4]hexatriaconta-3,6,9,12,20,23,26,35-octaene-14-carboximidic acid
Molecular weight1559.81
Hydrogen bond acceptor33
Hydrogen bond donor22
XlogP4.0
SynonymsN/A
Inchi KeyAPKRYKHCQYCPOP-GWRXOYJXSA-N
Inchi IDInChI=1S/C71H90N20O15S3/c1-37-61(97)85-51(25-39-9-4-3-5-10-39)66(102)90-56(68(104)84-50(60(74)96)24-41-16-20-46(93)21-17-41)34-109-108-33-55(89-63(99)48(72)23-40-14-18-45(92)19-15-40)69(105)86-52(27-44-30-77-36-80-44)64(100)81-38(2)62(98)88-54-32-107-35-59(95)91(31-43(83-67(54)103)11-8-22-78-71(75)76)57(26-42-29-79-49-13-7-6-12-47(42)49)70(106)87-53(28-58(73)94)65(101)82-37/h3-7,9-10,12-21,29-30,36-38,43,48,50-57,79,92-93H,8,11,22-28,31-35,72H2,1-2H3,(H2,73,94)(H2,74,96)(H,77,80)(H,81,100)(H,82,101)(H,83,103)(H,84,104)(H,85,97)(H,86,105)(H,87,106)(H,88,98)(H,89,99)(H,90,102)(H4,75,76,78)/t37-,38-,43-,48-,50-,51-,52-,53-,54+,55-,56-,57-/m0/s1
PubChem CID102096776
ChEMBLCHEMBL2323792
IUPHARN/A
BindingDB50427689
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC5020100.0 nMPMID23432160BindingDB,ChEMBL

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