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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thromboxane A2 receptor
Species	Rattus norvegicus (Rat)
Gene	Tbxa2r
Synonym	prostanoid TP receptor TP receptor TXA2-R TXR2
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLTLGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPSGQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQAMLSGP
UniProt	P34978
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3156
IUPHAR	346
DrugBank	N/A

Ligand

Name	CHEMBL162691
Molecular formula	C29H38N2O4
IUPAC name	(Z)-6-[(1R,2S,5R)-2-(azepan-1-yl)-5-[(4-pyridin-4-ylphenyl)methoxy]cyclopentyl]oxyhex-4-enoic acid
Molecular weight	478.633
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	1.9
Synonyms	BDBM50391300
Inchi Key	HCLFUHWPLXVRIS-HLOJMEPRSA-N
Inchi ID	InChI=1S/C29H38N2O4/c32-28(33)8-4-3-7-21-34-29-26(31-19-5-1-2-6-20-31)13-14-27(29)35-22-23-9-11-24(12-10-23)25-15-17-30-18-16-25/h3,7,9-12,15-18,26-27,29H,1-2,4-6,8,13-14,19-22H2,(H,32,33)/b7-3-/t26-,27+,29+/m0/s1
PubChem CID	15024095
ChEMBL	CHEMBL162691
IUPHAR	N/A
BindingDB	50391300
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	79.43 nM	Bioorg. Med. Chem. Lett., (1991) 1:12:695,	BindingDB,ChEMBL

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