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GPCR

NameGlucagon-like peptide 1 receptor
SpeciesHomo sapiens (Human)
GeneGLP1R
SynonymGLP-1-R
GLP-1 receptor
glucagon-like peptide 1 receptor
GLP-1R
DiseaseNon-insulin dependent diabetes
Type 2 diabetes
Type 1/2 diabetes
Type 1 diabetes
Obesity
[ Show all ]
Length463
Amino acid sequenceMAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProtP43220
Protein Data Bank5vew, 5otv, 3c5t, 4zgm, 3iol, 5otu, 5vex, 5otw, 5otx, 3c59, 5nx2
GPCR-HGmod modelP43220
3D structure modelThis structure is from PDB ID 5vew.
BioLiPBL0418500,BL0418501, BL0418494,BL0418495, BL0380967, BL0143732, BL0143731, BL0379513,BL0379514, BL0418496,BL0418497, BL0143795, BL0143794, BL0378791,BL0378792, BL0167480, BL0167479, BL0324355,BL0324356, BL0418498,BL0418499, BL0324354, BL0380966
Therapeutic Target DatabaseT36075
ChEMBLCHEMBL1784
IUPHAR249
DrugBankBE0000857

Ligand

NameAC1N3J05
Molecular formulaC20H27N5
IUPAC nameN,N-dibutyl-1-(3-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Molecular weight337.471
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP5.2
SynonymsCHEMBL1531550
HMS1910B22
NCGC00138872-01
EU-0028525
SR-01000566458
[ Show all ]
Inchi KeyABRYYIDYPOANDR-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H27N5/c1-4-6-11-24(12-7-5-2)19-18-14-23-25(20(18)22-15-21-19)17-10-8-9-16(3)13-17/h8-10,13-15H,4-7,11-12H2,1-3H3
PubChem CID4065518
ChEMBLCHEMBL1531550
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Potency10000.0 nMPubChem BioAssay data setChEMBL

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