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GPCR

NameLysophosphatidic acid receptor 3
SpeciesHomo sapiens (Human)
GeneLPAR3
SynonymLPA-3
Edg7
endothelial differentiation gene 7, lysophosphatidic acid G-protein-coupled receptor 7
LPA receptor 3
Lysophosphatidic acid receptor Edg-7
[ Show all ]
DiseaseFibrosis
Length353
Amino acid sequenceMNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
UniProtQ9UBY5
Protein Data BankN/A
GPCR-HGmod modelQ9UBY5
3D structure modelThis predicted structure model is from GPCR-EXP Q9UBY5.
BioLiPN/A
Therapeutic Target DatabaseT95923
ChEMBLCHEMBL3250
IUPHAR274
DrugBankN/A

Ligand

NameCHEMBL191411
Molecular formulaC34H54NO6P
IUPAC name[(2S)-2-(octadecanoylamino)-3-(4-phenylmethoxyphenyl)propyl] dihydrogen phosphate
Molecular weight603.781
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP9.7
SynonymsBDBM50170841
Phosphoric acid mono-[(S)-3-(4-benzyloxy-phenyl)-2-octadecanoylamino-propyl] ester
Inchi KeyHCYMVUMFVDONQB-YTTGMZPUSA-N
Inchi IDInChI=1S/C34H54NO6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-34(36)35-32(29-41-42(37,38)39)27-30-23-25-33(26-24-30)40-28-31-20-17-16-18-21-31/h16-18,20-21,23-26,32H,2-15,19,22,27-29H2,1H3,(H,35,36)(H2,37,38,39)/t32-/m0/s1
PubChem CID44397968
ChEMBLCHEMBL191411
IUPHARN/A
BindingDB50170841
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC501186.0 nMPMID16033271ChEMBL
Ki588.0 nMPMID16033271BindingDB,ChEMBL

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