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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL1078960
Molecular formulaC24H28N4O3S
IUPAC name1-[4-[[4-(2-amino-2-methylpropyl)phenyl]sulfamoyl]phenyl]-3-(4-methylphenyl)urea
Molecular weight452.573
Hydrogen bond acceptor5
Hydrogen bond donor4
XlogP3.3
SynonymsBDBM50311115
N-(4-(2-amino-2-methylpropyl)phenyl)-4-(3-p-tolylureido)benzenesulfonamide
Inchi KeyAPRNMJWYFKJVAT-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H28N4O3S/c1-17-4-8-19(9-5-17)26-23(29)27-20-12-14-22(15-13-20)32(30,31)28-21-10-6-18(7-11-21)16-24(2,3)25/h4-15,28H,16,25H2,1-3H3,(H2,26,27,29)
PubChem CID46882270
ChEMBLCHEMBL1078960
IUPHARN/A
BindingDB50311115
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity3.0 %PMID19767208ChEMBL
IC5077.0 nMPMID19767208BindingDB,ChEMBL

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