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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL1643957
Molecular formula	C25H24F3N7O2
IUPAC name	4-[[2-cyclohexyl-5-[4-(trifluoromethoxy)phenyl]pyrazol-3-yl]methyl]-N-(2H-tetrazol-5-yl)benzamide
Molecular weight	511.509
Hydrogen bond acceptor	9
Hydrogen bond donor	2
XlogP	5.5
Synonyms	4-((1-cyclohexyl-3-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-5-yl)methyl)-N-(2H-tetrazol-5-yl)benzamide APTSCLZAPPTCIL-UHFFFAOYSA-N 4-({1-Cyclohexyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methyl)-N-(1H-tetrazol-5-yl)benzamide BDBM50334497 SCHEMBL2251811
Inchi Key	APTSCLZAPPTCIL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H24F3N7O2/c26-25(27,28)37-21-12-10-17(11-13-21)22-15-20(35(32-22)19-4-2-1-3-5-19)14-16-6-8-18(9-7-16)23(36)29-24-30-33-34-31-24/h6-13,15,19H,1-5,14H2,(H2,29,30,31,33,34,36)
PubChem CID	10324098
ChEMBL	CHEMBL1643957
IUPHAR	N/A
BindingDB	50334497
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4200.0 nM	PMID21147532	BindingDB,ChEMBL

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