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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701924
Molecular formulaC18H19F3N2O2
IUPAC name4-[(2S)-morpholin-2-yl]-N-[[4-(trifluoromethoxy)phenyl]methyl]aniline
Molecular weight352.357
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP3.6
SynonymsSCHEMBL12609917
BDBM129383
US8802673, 25
Inchi KeyHFQWIWDTZQPAMR-QGZVFWFLSA-N
Inchi IDInChI=1S/C18H19F3N2O2/c19-18(20,21)25-16-7-1-13(2-8-16)11-23-15-5-3-14(4-6-15)17-12-22-9-10-24-17/h1-8,17,22-23H,9-12H2/t17-/m1/s1
PubChem CID68325652
ChEMBLCHEMBL3701924
IUPHARN/A
BindingDB129383
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki70.5 nM, NoneBindingDB,ChEMBL

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