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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3641712
Molecular formulaC15H18N4O
IUPAC name6-methyl-N-[4-[(2S)-morpholin-2-yl]phenyl]pyridazin-3-amine
Molecular weight270.336
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP1.1
SynonymsSCHEMBL12610333
BDBM129518
US8802673, 160
Inchi KeyHFUZOZOERXDHOL-CQSZACIVSA-N
Inchi IDInChI=1S/C15H18N4O/c1-11-2-7-15(19-18-11)17-13-5-3-12(4-6-13)14-10-16-8-9-20-14/h2-7,14,16H,8-10H2,1H3,(H,17,19)/t14-/m1/s1
PubChem CID68325862
ChEMBLCHEMBL3641712
IUPHARN/A
BindingDB129518
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2749.0 nM, NoneBindingDB,ChEMBL

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