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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	CHEMBL1916285
Molecular formula	C28H37N5O4S
IUPAC name	N-[(2S)-3,3-dimethylbutan-2-yl]-3-methyl-5-[[3-(morpholin-4-ylmethyl)phenyl]sulfonylamino]-1-phenylpyrazole-4-carboxamide
Molecular weight	539.695
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	4.6
Synonyms	N/A
Inchi Key	APVDYTYHJFKIEK-NRFANRHFSA-N
Inchi ID	InChI=1S/C28H37N5O4S/c1-20-25(27(34)29-21(2)28(3,4)5)26(33(30-20)23-11-7-6-8-12-23)31-38(35,36)24-13-9-10-22(18-24)19-32-14-16-37-17-15-32/h6-13,18,21,31H,14-17,19H2,1-5H3,(H,29,34)/t21-/m0/s1
PubChem CID	57392965
ChEMBL	CHEMBL1916285
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>25.0 %	PMID21955939	ChEMBL

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