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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL593344
Molecular formulaC15H16BrClN2OS
IUPAC name(2S)-N-(5-bromo-1,3-thiazol-2-yl)-2-(4-chlorophenyl)-3,3-dimethylbutanamide
Molecular weight387.72
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.5
SynonymsBDBM50305906
(S)-N-(5-bromothiazol-2-yl)-2-(4-chlorophenyl)-3,3-dimethylbutanamide
Inchi KeyHHAMRMFFHYQDHM-LBPRGKRZSA-N
Inchi IDInChI=1S/C15H16BrClN2OS/c1-15(2,3)12(9-4-6-10(17)7-5-9)13(20)19-14-18-8-11(16)21-14/h4-8,12H,1-3H3,(H,18,19,20)/t12-/m0/s1
PubChem CID46226275
ChEMBLCHEMBL593344
IUPHARN/A
BindingDB50305906
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy95.0 %PMID20005104ChEMBL
IC50700.0 nMPMID20005104BindingDB,ChEMBL

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