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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymGPCR105
H4 receptor
H4R
HH4R
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameCHEMBL493100
Molecular formulaC14H27N5
IUPAC name6-tert-butyl-4-N-[3-(dimethylamino)propyl]-4-N-methylpyrimidine-2,4-diamine
Molecular weight265.405
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.4
SynonymsSCHEMBL2169116
Inchi KeyHHUOEIIRDZFYGY-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H27N5/c1-14(2,3)11-10-12(17-13(15)16-11)19(6)9-7-8-18(4)5/h10H,7-9H2,1-6H3,(H2,15,16,17)
PubChem CID25128829
ChEMBLCHEMBL493100
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC509772.37 nMPMID18811133ChEMBL
Efficacy40.0 %PMID18811133ChEMBL

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