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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesHomo sapiens (Human)
GeneMCHR1
SynonymSLC-1
Somatostatin receptor-like protein
MCHR-1
MCHR
MCH1R
[ Show all ]
DiseaseObesity
Obesity; Anxiety; Depression
Length422
Amino acid sequenceMSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProtQ99705
Protein Data BankN/A
GPCR-HGmod modelQ99705
3D structure modelThis predicted structure model is from GPCR-EXP Q99705.
BioLiPN/A
Therapeutic Target DatabaseT09572
ChEMBLCHEMBL344
IUPHAR280
DrugBankBE0003478

Ligand

NameCHEMBL557317
Molecular formulaC22H18N4O
IUPAC nameN-(2-cyclopropylimidazo[1,2-a]pyridin-6-yl)-4-pyridin-2-ylbenzamide
Molecular weight354.413
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.8
SynonymsBDBM50297060
N-(2-cyclopropylimidazo[1,2-a]pyridin-6-yl)-4-(pyridin-2-yl)benzamide
Inchi KeyAQDSANBSLIXFAX-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H18N4O/c27-22(17-8-6-15(7-9-17)19-3-1-2-12-23-19)24-18-10-11-21-25-20(16-4-5-16)14-26(21)13-18/h1-3,6-14,16H,4-5H2,(H,24,27)
PubChem CID45273638
ChEMBLCHEMBL557317
IUPHARN/A
BindingDB50297060
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50140.0 nMPMID19615899BindingDB,ChEMBL

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