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Name | Nociceptin receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Oprl1 |
Synonym | NOP receptor NOP-r NOPr OP4 Orphanin FQ receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 367 |
Amino acid sequence | MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA |
UniProt | P35370 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4503 |
IUPHAR | 320 |
DrugBank | N/A |
Name | CHEMBL2403216 |
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Molecular formula | C50H71N15O10 |
IUPAC name | (2S)-2-[[(2R)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-2-(5-methoxy-1H-indol-3-yl)propanoyl]amino]-6-aminohexanamide |
Molecular weight | 1042.21 |
Hydrogen bond acceptor | 13 |
Hydrogen bond donor | 15 |
XlogP | -1.2 |
Synonyms | N/A |
Inchi Key | AQFOFSMOQYNDBF-NLDSVXPCSA-N |
Inchi ID | InChI=1S/C50H71N15O10/c1-28(66)61-40(9-6-22-58-50(55)56)46(72)64-42(24-30-12-16-32(68)17-13-30)48(74)65-41(23-29-10-14-31(67)15-11-29)47(73)63-39(8-5-21-57-49(53)54)45(71)60-27-36(44(70)62-38(43(52)69)7-3-4-20-51)35-26-59-37-19-18-33(75-2)25-34(35)37/h10-19,25-26,36,38-42,59,67-68H,3-9,20-24,27,51H2,1-2H3,(H2,52,69)(H,60,71)(H,61,66)(H,62,70)(H,63,73)(H,64,72)(H,65,74)(H4,53,54,57)(H4,55,56,58)/t36-,38-,39-,40-,41-,42-/m0/s1 |
PubChem CID | 71714523 |
ChEMBL | CHEMBL2403216 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 1412.54 nM | PMID23768905 | ChEMBL |
EC50 | 1659.59 nM | PMID23768905 | ChEMBL |
Emax | -52.0 % | PMID23768905 | ChEMBL |
Emax | -12.0 % | PMID23768905 | ChEMBL |
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