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GPCR

NameGrowth hormone-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneGhrhr
SynonymGhrfr
GHRH receptor
GRF receptor
GRFR
Growth hormone-releasing factor receptor
DiseaseN/A for non-human GPCRs
Length464
Amino acid sequenceMDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProtQ02644
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3709
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1791203
Molecular formulaC147H243N43O41S
IUPAC name(3S)-4-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
Molecular weight3300.88
Hydrogen bond acceptor48
Hydrogen bond donor48
XlogP-12.1
SynonymsN/A
Inchi KeyHJNUKERJLSBKPQ-PGUSOSMPSA-N
Inchi IDInChI=1S/C147H243N43O41S/c1-21-76(13)114(188-121(208)81(18)166-131(218)103(65-111(200)201)175-119(206)78(15)164-122(209)88(150)61-84-40-44-86(195)45-41-84)143(230)182-101(62-83-33-24-23-25-34-83)136(223)190-116(82(19)194)144(231)183-102(64-109(152)198)135(222)186-107(70-193)140(227)180-100(63-85-42-46-87(196)47-43-85)134(221)173-93(39-32-55-162-147(158)159)125(212)172-91(36-27-29-52-149)129(216)187-113(75(11)12)141(228)181-96(57-71(3)4)123(210)163-67-110(199)168-94(48-49-108(151)197)127(214)178-99(60-74(9)10)133(220)185-105(68-191)138(225)167-79(16)118(205)170-92(38-31-54-161-146(156)157)124(211)171-90(35-26-28-51-148)126(213)177-98(59-73(7)8)132(219)179-97(58-72(5)6)130(217)165-80(17)120(207)176-104(66-112(202)203)137(224)189-115(77(14)22-2)142(229)174-95(50-56-232-20)128(215)184-106(69-192)139(226)169-89(117(153)204)37-30-53-160-145(154)155/h23-25,33-34,40-47,71-82,88-107,113-116,191-196H,21-22,26-32,35-39,48-70,148-150H2,1-20H3,(H2,151,197)(H2,152,198)(H2,153,204)(H,163,210)(H,164,209)(H,165,217)(H,166,218)(H,167,225)(H,168,199)(H,169,226)(H,170,205)(H,171,211)(H,172,212)(H,173,221)(H,174,229)(H,175,206)(H,176,207)(H,177,213)(H,178,214)(H,179,219)(H,180,227)(H,181,228)(H,182,230)(H,183,231)(H,184,215)(H,185,220)(H,186,222)(H,187,216)(H,188,208)(H,189,224)(H,190,223)(H,200,201)(H,202,203)(H4,154,155,160)(H4,156,157,161)(H4,158,159,162)/t76-,77-,78-,79-,80-,81-,82+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,113-,114-,115-,116-/m0/s1
PubChem CID56671593
ChEMBLCHEMBL1791203
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Relative potency1.3 -PMID9513600ChEMBL

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