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GPCR

NameD(1A) dopamine receptor
SpeciesMus musculus (Mouse)
GeneDrd1
SynonymD1 receptor
D1A
DADR
Dopamine D1 receptor
Dopamine-1A receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProtQ61616
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3071
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL465055
Molecular formulaC19H21NO3
IUPAC name(6aR)-2-ethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
Molecular weight311.381
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP2.6
SynonymsBDBM50251320
(R)-2-Ethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
Inchi KeyAQIUGBDBNRZYIA-OAHLLOKOSA-N
Inchi IDInChI=1S/C19H21NO3/c1-3-23-13-8-12-6-7-20(2)15-9-11-4-5-16(21)19(22)18(11)14(10-13)17(12)15/h4-5,8,10,15,21-22H,3,6-7,9H2,1-2H3/t15-/m1/s1
PubChem CID44567587
ChEMBLCHEMBL465055
IUPHARN/A
BindingDB50251320
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2900.0 nMPMID18313931BindingDB,ChEMBL

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