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GPCR

Name5-hydroxytryptamine receptor 5A
SpeciesHomo sapiens (Human)
GeneHTR5A
Synonym5-HT5alpha
5-HT-5
MR22
Htr5
5-HT-5A
[ Show all ]
DiseaseN/A
Length357
Amino acid sequenceMDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProtP47898
Protein Data BankN/A
GPCR-HGmod modelP47898
3D structure modelThis predicted structure model is from GPCR-EXP P47898.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3426
IUPHAR10
DrugBankBE0004688

Ligand

NameCHEMBL103388
Molecular formulaC24H31N5O3S
IUPAC nameN-[4-[[5-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1,1-dioxo-1,2,5-thiadiazolidin-2-yl]methyl]phenyl]acetamide
Molecular weight469.604
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP1.8
SynonymsBDBM50422029
SCHEMBL8807080
2-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-5-[4-(acetylamino)benzyl]-1,2,5-thiadiazolidine 1,1-dioxide
Inchi KeyHLROMXIAWNSEJU-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H31N5O3S/c1-18(30)26-22-7-4-19(5-8-22)16-28-12-13-29(33(28,31)32)17-20-6-9-24-23(14-20)21(15-25-24)10-11-27(2)3/h4-9,14-15,25H,10-13,16-17H2,1-3H3,(H,26,30)
PubChem CID10412397
ChEMBLCHEMBL103388
IUPHARN/A
BindingDB50422029
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50199.53 nMPMID7932524ChEMBL
IC50200.0 nMPMID7932524BindingDB

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