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GPCR

NameCannabinoid receptor 1
SpeciesMus musculus (Mouse)
GeneCnr1
SynonymSKR6R
Neuronal cannabinoid receptor
Central cannabinoid receptor
CB1R
CB1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length473
Amino acid sequenceMKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
UniProtP47746
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3037
IUPHAR56
DrugBankN/A

Ligand

NameCHEMBL3290443
Molecular formulaC21H18Cl2N4O3
IUPAC name1-(2,4-dichlorophenyl)-6-methyl-N-morpholin-4-yl-[1]benzofuro[3,2-c]pyrazole-3-carboxamide
Molecular weight445.3
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP4.8
SynonymsSCHEMBL2910026
BDBM50020593
Inchi KeyABUBFFJYPALUKU-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H18Cl2N4O3/c1-12-2-4-14-17(10-12)30-20-18(21(28)25-26-6-8-29-9-7-26)24-27(19(14)20)16-5-3-13(22)11-15(16)23/h2-5,10-11H,6-9H2,1H3,(H,25,28)
PubChem CID59450137
ChEMBLCHEMBL3290443
IUPHARN/A
BindingDB50020593
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki4064.0 nMPMID24922543BindingDB,ChEMBL

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