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GPCR

NameProstaglandin F2-alpha receptor
SpeciesHomo sapiens (Human)
GenePTGFR
SynonymProstanoid FP receptor
prostaglandin F2-alpha receptor
prostaglandin F receptor (FP)
prostaglandin F receptor
PGF2-alpha receptor
[ Show all ]
DiseaseGlaucoma
Ocular disease
Renal cancer
Dysmenorrhea
Alzheimer disease
[ Show all ]
Length359
Amino acid sequenceMSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProtP43088
Protein Data BankN/A
GPCR-HGmod modelP43088
3D structure modelThis predicted structure model is from GPCR-EXP P43088.
BioLiPN/A
Therapeutic Target DatabaseT75797
ChEMBLCHEMBL1987
IUPHAR344
DrugBankBE0000610

Ligand

NameCHEMBL563949
Molecular formulaC16H12F2N2O4S
IUPAC name2-[1-(3,4-difluorophenyl)sulfonyl-2-methylpyrrolo[2,3-b]pyridin-3-yl]acetic acid
Molecular weight366.339
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP2.6
Synonyms[1-(3,4-difluoro-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid
BDBM50296848
HLSYGDSWXJGENX-UHFFFAOYSA-N
2-(1-(3,4-difluorophenylsulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid
SCHEMBL1940356
Inchi KeyHLSYGDSWXJGENX-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H12F2N2O4S/c1-9-12(8-15(21)22)11-3-2-6-19-16(11)20(9)25(23,24)10-4-5-13(17)14(18)7-10/h2-7H,8H2,1H3,(H,21,22)
PubChem CID11667741
ChEMBLCHEMBL563949
IUPHARN/A
BindingDB50296848
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<10000.0 nMPMID19592244BindingDB,ChEMBL

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