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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL2022258
Molecular formulaC26H26O4
IUPAC name2-[6-[[3-(2,4,6-trimethylphenyl)phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid
Molecular weight402.49
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP5.4
SynonymsSCHEMBL3450662
BDBM50382538
Inchi KeyAQKJHSVMUFRPBD-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H26O4/c1-16-9-17(2)26(18(3)10-16)20-6-4-5-19(11-20)14-29-22-7-8-23-21(12-25(27)28)15-30-24(23)13-22/h4-11,13,21H,12,14-15H2,1-3H3,(H,27,28)
PubChem CID23111766
ChEMBLCHEMBL2022258
IUPHARN/A
BindingDB50382538
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC5033.0 nMPMID22242551BindingDB,ChEMBL
Ki36.0 nMPMID22242551BindingDB,ChEMBL

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