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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameC-C chemokine receptor type 8
SpeciesHomo sapiens (Human)
GeneCCR8
SynonymGPRCY6
GPR-CY6
CMKBRL2
CKR-L1
ChemR1
[ Show all ]
DiseasePsoriasis
Length355
Amino acid sequenceMDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
UniProtP51685
Protein Data BankN/A
GPCR-HGmod modelP51685
3D structure modelThis predicted structure model is from GPCR-EXP P51685.
BioLiPN/A
Therapeutic Target DatabaseT20575
ChEMBLCHEMBL4596
IUPHAR65
DrugBankN/A

Ligand

NameCHEMBL393411
Molecular formulaC25H26N4O3
IUPAC name3-[3-(1H-indol-2-ylmethylamino)propyl]-5-(6-methoxyquinolin-4-yl)-1,3-oxazolidin-2-one
Molecular weight430.508
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP3.3
SynonymsSCHEMBL3930474
BDBM50423257
Inchi KeyAQOIKSICNYLNIQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H26N4O3/c1-31-19-7-8-23-21(14-19)20(9-11-27-23)24-16-29(25(30)32-24)12-4-10-26-15-18-13-17-5-2-3-6-22(17)28-18/h2-3,5-9,11,13-14,24,26,28H,4,10,12,15-16H2,1H3
PubChem CID44439837
ChEMBLCHEMBL393411
IUPHARN/A
BindingDB50423257
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501584.89 nMPMID17267215ChEMBL
IC501585.0 nMPMID17267215BindingDB

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