You can:
Name | Alpha-2A adrenergic receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | ADRA2A |
Synonym | alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A [ Show all ] |
Disease | Attention deficit hyperactivity disorder Sexual dysfunction Pain |
Length | 450 |
Amino acid sequence | MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV |
UniProt | P08913 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08913 |
3D structure model | This predicted structure model is from GPCR-EXP P08913. |
BioLiP | N/A |
Therapeutic Target Database | T11448 |
ChEMBL | CHEMBL1867 |
IUPHAR | 25 |
DrugBank | BE0000289 |
Name | IDAZOXAN |
---|---|
Molecular formula | C11H12N2O2 |
IUPAC name | 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole |
Molecular weight | 204.229 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 0.7 |
Synonyms | Idazoxano NCGC00015560-05 Prestwick0_000926 Tox21 110173 2-(1,4-benzodioxan-2-yl)imidazoline [ Show all ] |
Inchi Key | HPMRFMKYPGXPEP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13) |
PubChem CID | 54459 |
ChEMBL | CHEMBL10316 |
IUPHAR | N/A |
BindingDB | 50019848 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 8.3 nM | PMID10636247 | BindingDB |
IC50 | 8.318 nM | PMID10636247 | ChEMBL |
Ki | 1.9 nM | PMID1656026 | BindingDB |
Ki | 7.079 nM | PMID18578476, PMID22370341 | ChEMBL |
Ki | 7.1 nM | PMID18578476, PMID22370341 | BindingDB |
Ki | 8.0 nM | PMID17257841 | PDSP,BindingDB,ChEMBL |
Ki | 9.77 nM | PMID9605427 | BindingDB |
Ki | 9.77237 nM | PMID9605427 | PDSP |
pKb | 7.73 - | PMID18578476, PMID22370341 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218