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GPCR

NameAlpha-2C adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRA2C
Synonymalpha2-C4
Adra-2c
ADRA2L2
ADRA2RL2
Adrenergic alpha2C- receptor class I
[ Show all ]
DiseaseDiabetic nephropathy; Fibromyalgia
Hypertension
Heart failure
Glaucoma
Alzheimer disease
[ Show all ]
Length462
Amino acid sequenceMASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProtP18825
Protein Data BankN/A
GPCR-HGmod modelP18825
3D structure modelThis predicted structure model is from GPCR-EXP P18825.
BioLiPN/A
Therapeutic Target DatabaseT01777
ChEMBLCHEMBL1916
IUPHAR27
DrugBankBE0004864, BE0000342, BE0004888

Ligand

NameIDAZOXAN
Molecular formulaC11H12N2O2
IUPAC name2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole
Molecular weight204.229
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP0.7
SynonymsIdazoxano
NCGC00015560-05
Prestwick0_000926
Tox21 110173
2-(1,4-benzodioxan-2-yl)imidazoline
[ Show all ]
Inchi KeyHPMRFMKYPGXPEP-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13)
PubChem CID54459
ChEMBLCHEMBL10316
IUPHARN/A
BindingDB50019848
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5053.7 nMPMID10636247ChEMBL
IC5054.0 nMPMID10636247BindingDB
Ki17.78 nMPMID18578476, PMID22370341ChEMBL
Ki18.0 nMPMID18578476, PMID22370341BindingDB
Ki19.0 nMPMID17257841PDSP,BindingDB,ChEMBL
Ki19.95 nMPMID9605427BindingDB
Ki19.9526 nMPMID9605427PDSP
pKb7.92 -PMID18578476, PMID22370341ChEMBL

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