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GPCR

NameDelta-type opioid receptor
SpeciesHomo sapiens (Human)
GeneOPRD1
SynonymDOP
OP1
DOR-1
DOR
D-OR-1
[ Show all ]
DiseaseUrinary incontinence
Rheumatoid arthritis
Premature ejaculation
Pain
Overactive bladder disorder
[ Show all ]
Length372
Amino acid sequenceMEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
UniProtP41143
Protein Data Bank4n6h, 4rwd, 4rwa
GPCR-HGmod modelP41143
3D structure modelThis structure is from PDB ID 4n6h.
BioLiPBL0265712, BL0265705,BL0265706,BL0265707,, BL0303699,BL0303701, BL0303698,BL0303700, BL0303696,BL0303697
Therapeutic Target DatabaseT58992
ChEMBLCHEMBL236
IUPHAR317
DrugBankBE0000420

Ligand

NameAC1NB6ST
Molecular formulaC26H35N5O6
IUPAC name2-amino-N-[1-[[2-[[1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide
Molecular weight513.595
Hydrogen bond acceptor7
Hydrogen bond donor6
XlogP0.2
SynonymsSCHEMBL19987691
BDBM86253
Tyr-D- Ala-Gly-N-Methyl-Phe-Gly-ol
NSC_104742
CAS_100929-53-1
[ Show all ]
Inchi KeyHPZJMUBDEAMBFI-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)
PubChem CID4488326
ChEMBLN/A
IUPHARN/A
BindingDB86253
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki200.0 nMPMID7932177PDSP
Ki300.0 nMPMID9686407PDSP
Ki1000.0 nMPMID8114680PDSP
Ki1430.0 nMPMID14534366PDSP

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