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GPCR

Name	Mu-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprm1
Synonym	Opioid receptor B opioid receptor OP3 mu receptor MOR-1 MOPr MOP M-OR-1 opioid receptor, mu 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P33535
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL270
IUPHAR	319
DrugBank	N/A

Ligand

Name	DAMGO
Molecular formula	C26H35N5O6
IUPAC name	(2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide
Molecular weight	513.595
Hydrogen bond acceptor	7
Hydrogen bond donor	6
XlogP	0.2
Synonyms	ZINC53092426 (2S)-2-amino-N-[(1R)-2-[[2-[[(1S)-1-benzyl-2-(2-hydroxyethylamino)-2-oxo-ethyl]-methyl-amino]-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]-3-(4-hydroxyphenyl)propanamide 2-Ala-4-mephe-5-gly-enkephalin AC1Q29AA CHEBI:272 Dagol glyol MolPort-023-276-021 Tyr-D-Ala-Gly-N(CH3)Phe-Gly-ol [tyrosyl-3,5-3H(N)]-D-Ala2-Mephe4-glyol5-enkephalin (2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide 83314-80-1 Ala2-MePhe4-Glyol5-Enkephalin CS-0021316 DTXSID30228775 H-Tyr-D-Ala-Gly-N-Me-Phe-Glycinol SCHEMBL725750 Tyr-D-Ala-Gly-N-Methyl-Phe-Gly-ol Tyr-D-Ala2-Gly-NMePhe-Gly-ol 117592-80-0 97777-48-5 C-54725 DAGn Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)- L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl- Tyr-D-Ala-Gly-MePhe-Gly(ol) [3H]DAMGO (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide AKOS024456435 DAMGE GTPL1647 NCGC00167303-01 Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin 91418-78-9 B6621 D-Ala2-MePhe4-Met(0)5-enkephalin-ol Enkephalin, ala(2)-mephe(4)-gly(5)- HPZJMUBDEAMBFI-WTNAPCKOSA-N Tyr-ala-gly-(nme)phe-gly-ol Tyr-D-Ala-Gly-NMe-Phe-Gly-ol Tyr-DAla-Gly-MePhe-Gly-ol AC1NUWDS C11318 DAGO FT-0772476 LS-105734 Tyr-D-Ala-Gly-MePhe-Gly-ol [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin (2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]-methylamino]-N-(2-hydroxyethyl)-3-phenylpropanamide 78123-71-4 Ala(2)-mephe(4)-gly-ol(5) enkephalin CHEMBL38874 H-Tyr-D-Ala-Gly-MePhe-Gly-ol RX 783006 Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol (S)-2-amino-N-((R)-1-(2-(((S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl)(methyl)amino)-2-oxoethylamino)-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)propanamide 950492-85-0 BDBM21015 D0F8CV Enkephalin, Ala(2)-MePhe(4)-Gly-ol(5)- HY-P0210 Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol Tyr-D-Ala-Gly-NMePhe-Gly-ol [ Show all ]
Inchi Key	HPZJMUBDEAMBFI-WTNAPCKOSA-N
Inchi ID	InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
PubChem CID	5462471
ChEMBL	CHEMBL38874
IUPHAR	1647
BindingDB	21015
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Activity	76.0 %	PMID19640720	ChEMBL
Bmax	1207.0 fM mg-1	PMID10866377	ChEMBL
EC50	36.0 nM	PMID20560643, PMID16509592	BindingDB
EC50	36.31 nM	PMID19762245, PMID16686530, PMID17516639, PMID20617791, PMID20560643, PMID21366266, PMID21128594, PMID16509592	ChEMBL
EC50	37.0 nM	PMID18821747, PMID17927164, PMID19762245, PMID16686530, PMID17516639, PMID20617791, PMID20560643, PMID21366266, PMID21128594, PMID16509592, PMID18266313	BindingDB,ChEMBL
EC50	40.0 nM	PMID18821747	BindingDB
EC50	81.0 nM	PMID25221662	BindingDB,ChEMBL
EC50	145.0 nM	PMID18572932	BindingDB,ChEMBL
EC50	214.0 nM	PMID21287991	BindingDB,ChEMBL
EC50	485.0 nM	PMID22957923	BindingDB,ChEMBL
Emax	119.0 %	PMID21287991	ChEMBL
Emax	150.0 %	PMID18821747, PMID19762245, PMID16686530, PMID17516639, PMID20617791, PMID20560643, PMID21366266, PMID21128594, PMID16509592, PMID18266313	ChEMBL
Emax	169.0 %	PMID18062664	ChEMBL
Emax	170.0 %	PMID18572932	ChEMBL
Emax	173.0 %	PMID22957923	ChEMBL
Emax	178.0 %	PMID21287991	ChEMBL
Emax	465.2 %	PMID25221662	ChEMBL
IC50	1.01 nM	PMID19640720	BindingDB,ChEMBL
IC50	1.13 nM	PMID17395470	BindingDB,ChEMBL
IC50	3.0 nM	PMID9873480	BindingDB,ChEMBL
IC50	3.5 nM	PMID10543877	BindingDB,ChEMBL
IC50	9.89 nM	PMID11133084	ChEMBL
IC50	9.9 nM	PMID11133084, PMID12036366, PMID15456262	BindingDB,ChEMBL
IC50	9.9 nM	PMID15456262	BindingDB
IC50	36.31 nM	PMID19762245	ChEMBL
Kd	0.5 nM	PMID18266313	BindingDB
Kd	0.85 nM	PMID16686530, PMID17927164	BindingDB
Ki	0.0024 nM	PMID18062664	BindingDB,ChEMBL
Ki	0.365 nM	PMID7562497	BindingDB
Ki	0.53 nM	PMID10866377	ChEMBL
Ki	0.53 nM	PMID10866377	BindingDB
Ki	0.62 nM	PMID9694962	BindingDB
Ki	0.66 nM	PMID1849997	ChEMBL
Ki	0.66 nM	PMID1849997	BindingDB
Ki	0.85 nM	PMID20617791	ChEMBL
Ki	0.85 nM	PMID20617791	BindingDB
Ki	0.87 nM	PMID20599386	ChEMBL
Ki	0.87 nM	PMID20599386	BindingDB
Ki	1.0 nM	PMID25221662	ChEMBL
Ki	1.0 nM	PMID25221662	BindingDB
Ki	1.1 nM	PMID10585536	BindingDB
Ki	1.16 nM	PMID9700760	BindingDB
Ki	1.2 nM	PMID2537427	BindingDB
Ki	1.22 nM	PMID2537427	ChEMBL
Ki	1.29 nM	PMID9700760	BindingDB
Ki	1.49 nM	PMID9694962	BindingDB
Ki	1.6 nM	PMID11133084, PMID12036366, PMID15456262	BindingDB,ChEMBL
Ki	1.64 nM	PMID11133084	ChEMBL
Ki	1.7 nM	PMID23974016	ChEMBL
Ki	1.9 nM	PMID3033464	BindingDB
Ki	1.99526 nM	PMID8114680	IUPHAR
Ki	3.9 nM	PMID2828622, PMID1714957	BindingDB,ChEMBL
Ki	4.0 nM	PMID8064796	BindingDB,ChEMBL
Ki	6.1 nM	PMID14998329	BindingDB,ChEMBL
Ki	16.0 nM	PMID19762245	BindingDB,ChEMBL
Log10ED50	6.71 -	PMID18062664	ChEMBL
logEC50	-7.4 -	PMID18266313	ChEMBL
logIC50	8.62 -	PMID23974016	ChEMBL
pEC50	7.4 nM	PMID18821747	ChEMBL
Relative potency	7.73 -	PMID2537427	ChEMBL