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Name | Kappa-type opioid receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | OPRK1 |
Synonym | K-OR-1 KOPr OP2 KOP KOR-1 [ Show all ] |
Disease | Obesity Opiate dependence Inflammatory bowel disease Erythema Diarrhea-predominant IBS [ Show all ] |
Length | 380 |
Amino acid sequence | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV |
UniProt | P41145 |
Protein Data Bank | 6b73, 4djh |
GPCR-HGmod model | P41145 |
3D structure model | This structure is from PDB ID 6b73. |
BioLiP | BL0402244,BL0402246, BL0224693,BL0224694, BL0402243,BL0402245 |
Therapeutic Target Database | T60693 |
ChEMBL | CHEMBL237 |
IUPHAR | 318 |
DrugBank | BE0000632 |
Name | DAMGO |
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Molecular formula | C26H35N5O6 |
IUPAC name | (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide |
Molecular weight | 513.595 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 6 |
XlogP | 0.2 |
Synonyms | SCHEMBL725750 Tyr-D-Ala-Gly-N-Methyl-Phe-Gly-ol [tyrosyl-3,5-3H(N)]-D-Ala2-Mephe4-glyol5-enkephalin (2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide 83314-80-1 [ Show all ] |
Inchi Key | HPZJMUBDEAMBFI-WTNAPCKOSA-N |
Inchi ID | InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1 |
PubChem CID | 5462471 |
ChEMBL | CHEMBL38874 |
IUPHAR | 1647 |
BindingDB | 21015 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 100.0 % | PMID21866885 | ChEMBL |
EC50 | 4000.0 nM | PMID23880538 | ChEMBL |
EC50 | 4365.0 nM | PMID12672258 | BindingDB,ChEMBL |
ED50 | 8940.0 nM | PMID20055417 | ChEMBL |
Emax | 69.0 % | PMID20055417 | ChEMBL |
Inhibition | 66.0 % | PMID23880538 | ChEMBL |
Ki | <1000.0 nM | PMID12699761 | BindingDB,ChEMBL |
Ki | <2000.0 nM | PMID15380196 | BindingDB,ChEMBL |
Ki | <10000.0 nM | PMID9651168 | BindingDB,ChEMBL |
Ki | 18.3 nM | PMID7932177 | BindingDB |
Ki | 270.0 nM | PMID26125201 | BindingDB,ChEMBL |
Ki | 305.0 nM | PMID12672258 | BindingDB,ChEMBL |
Ki | 305.5 nM | PMID9686407 | BindingDB |
Ki | 306.0 nM | PMID21866885 | BindingDB,ChEMBL |
Ki | 316.228 nM | PMID9686407 | IUPHAR |
Ki | 1000.0 nM | PMID8114680 | BindingDB |
Stimulation | 62.0 % | PMID12672258 | ChEMBL |
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