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Name | Mu-type opioid receptor |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | OPRM1 |
Synonym | M-OR-1 MOR-1 |
Disease | N/A for non-human GPCRs |
Length | 98 |
Amino acid sequence | YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI |
UniProt | P97266 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4354 |
IUPHAR | N/A |
DrugBank | N/A |
Name | DAMGO |
---|---|
Molecular formula | C26H35N5O6 |
IUPAC name | (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide |
Molecular weight | 513.595 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 6 |
XlogP | 0.2 |
Synonyms | Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol [3H]DAMGO (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide AKOS024456435 DAMGE [ Show all ] |
Inchi Key | HPZJMUBDEAMBFI-WTNAPCKOSA-N |
Inchi ID | InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1 |
PubChem CID | 5462471 |
ChEMBL | CHEMBL38874 |
IUPHAR | 1647 |
BindingDB | 21015 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 158.0 nM | PMID27234885 | BindingDB |
EC50 | 158.49 nM | PMID27234885 | ChEMBL |
EC50 | 414.0 - | PMID14998329 | ChEMBL |
EC50 | 414.0 nM | PMID14998329 | BindingDB |
ED50 | 592.0 nM | PMID11300879 | ChEMBL |
Emax | 100.0 % | PMID14998329 | ChEMBL |
Emax | 123.0 - | PMID10571174 | ChEMBL |
Emax | 123.0 nM | PMID10612597, PMID11300879 | ChEMBL |
IC50 | 11.5 nM | PMID2828622 | ChEMBL |
IC50 | 12.0 nM | PMID2828622 | BindingDB |
Kd | 592.0 nM | PMID10571174, PMID10612597 | BindingDB,ChEMBL |
Ke | 25.3 nM | PMID10794701 | ChEMBL |
Ki | 0.99 nM | PMID9873602 | ChEMBL |
Ki | 0.99 nM | PMID9873602 | BindingDB |
Ki | 1.1 nM | PMID16777416, PMID9686407 | BindingDB,ChEMBL |
Ki | 2.6 nM | PMID10585536 | BindingDB |
Ki | 6.0 nM | PMID6248635 | BindingDB |
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