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GPCR

NameMu-type opioid receptor
SpeciesCavia porcellus (Guinea pig)
GeneOPRM1
SynonymM-OR-1
MOR-1
DiseaseN/A for non-human GPCRs
Length98
Amino acid sequenceYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI
UniProtP97266
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4354
IUPHARN/A
DrugBankN/A

Ligand

NameDAMGO
Molecular formulaC26H35N5O6
IUPAC name(2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide
Molecular weight513.595
Hydrogen bond acceptor7
Hydrogen bond donor6
XlogP0.2
SynonymsTyr-D-Ala-Gly-N(Me)Phe-Gly-ol
[3H]DAMGO
(2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide
AKOS024456435
DAMGE
[ Show all ]
Inchi KeyHPZJMUBDEAMBFI-WTNAPCKOSA-N
Inchi IDInChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
PubChem CID5462471
ChEMBLCHEMBL38874
IUPHAR1647
BindingDB21015
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50158.0 nMPMID27234885BindingDB
EC50158.49 nMPMID27234885ChEMBL
EC50414.0 -PMID14998329ChEMBL
EC50414.0 nMPMID14998329BindingDB
ED50592.0 nMPMID11300879ChEMBL
Emax100.0 %PMID14998329ChEMBL
Emax123.0 -PMID10571174ChEMBL
Emax123.0 nMPMID10612597, PMID11300879ChEMBL
IC5011.5 nMPMID2828622ChEMBL
IC5012.0 nMPMID2828622BindingDB
Kd592.0 nMPMID10571174, PMID10612597BindingDB,ChEMBL
Ke25.3 nMPMID10794701ChEMBL
Ki0.99 nMPMID9873602ChEMBL
Ki0.99 nMPMID9873602BindingDB
Ki1.1 nMPMID16777416, PMID9686407BindingDB,ChEMBL
Ki2.6 nMPMID10585536BindingDB
Ki6.0 nMPMID6248635BindingDB

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