You can:
Name | Mu-type opioid receptor |
---|---|
Species | Mus musculus (Mouse) |
Gene | Oprm1 |
Synonym | opioid receptor, mu 1 opioid receptor OP3 Mu receptor MOR-1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 398 |
Amino acid sequence | MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP |
UniProt | P42866 |
Protein Data Bank | 4dkl, 5c1m, 6dde, 6ddf |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 4dkl. |
BioLiP | BL0416752, BL0416751, BL0321492, BL0224753, BL0224754, BL0224755,BL0224756, BL0321491 |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2858 |
IUPHAR | 319 |
DrugBank | N/A |
Name | DAMGO |
---|---|
Molecular formula | C26H35N5O6 |
IUPAC name | (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide |
Molecular weight | 513.595 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 6 |
XlogP | 0.2 |
Synonyms | (2S)-2-amino-N-[(1R)-2-[[2-[[(1S)-1-benzyl-2-(2-hydroxyethylamino)-2-oxo-ethyl]-methyl-amino]-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]-3-(4-hydroxyphenyl)propanamide 2-Ala-4-mephe-5-gly-enkephalin AC1Q29AA CHEBI:272 Dagol [ Show all ] |
Inchi Key | HPZJMUBDEAMBFI-WTNAPCKOSA-N |
Inchi ID | InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1 |
PubChem CID | 5462471 |
ChEMBL | CHEMBL38874 |
IUPHAR | 1647 |
BindingDB | 21015 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 5.0 nM | PMID23880538 | ChEMBL |
EC50 | 5.6 nM | PMID24103580 | ChEMBL |
IC50 | 75.55 nM | PMID18062664 | BindingDB,ChEMBL |
Inhibition | 95.0 % | PMID23880538 | ChEMBL |
Ki | 0.62 nM | PMID9694962 | BindingDB |
Ki | 0.82 nM | PMID9694962 | BindingDB |
Ki | 0.83 nM | PMID25248680 | ChEMBL |
Ki | 0.83 nM | PMID25248680 | BindingDB |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218