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GPCR

Name	Gastrin/cholecystokinin type B receptor
Species	Homo sapiens (Human)
Gene	CCKBR
Synonym	CCK-B receptor CCK-B receptor {ECO:0000303\|PubMed:8415658} CCK-B/gastrin receptor CCK-BR gastrin/cholecystokinin type B receptor CCK2 receptor CCK2-R CHOLREC Cholecystokinin-2 receptor {ECO:0000303\|PubMed:11926817} cholecystokinin-2 receptor [ Show all ]
Disease	Diagnostic imaging Duodenal ulcers Gastroesophageal reflux disease Gastrointestinal disease Intestine cancer Medullary thyroid cancer Stomach disease Stomach ulcer Type 1 diabetes Ulcerative colitis Unspecified Anxiety disorder Caerulein stimulated gastric and pancreatic secretion Cancer [ Show all ]
Length	447
Amino acid sequence	MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
UniProt	P32239
Protein Data Bank	N/A
GPCR-HGmod model	P32239
3D structure model	This predicted structure model is from GPCR-EXP P32239.
BioLiP	N/A
Therapeutic Target Database	T05849
ChEMBL	CHEMBL298
IUPHAR	77
DrugBank	BE0001158

Ligand

Name	DAMGO
Molecular formula	C26H35N5O6
IUPAC name	(2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide
Molecular weight	513.595
Hydrogen bond acceptor	7
Hydrogen bond donor	6
XlogP	0.2
Synonyms	AC1NUWDS C11318 DAGO FT-0772476 LS-105734 Tyr-D-Ala-Gly-MePhe-Gly-ol Tyr-DAla-Gly-MePhe-Gly-ol (2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]-methylamino]-N-(2-hydroxyethyl)-3-phenylpropanamide 78123-71-4 Ala(2)-mephe(4)-gly-ol(5) enkephalin CHEMBL38874 H-Tyr-D-Ala-Gly-MePhe-Gly-ol RX 783006 Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin (S)-2-amino-N-((R)-1-(2-(((S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl)(methyl)amino)-2-oxoethylamino)-1-oxopropan-2-yl)-3-(4-hydroxyphenyl)propanamide 950492-85-0 BDBM21015 D0F8CV Enkephalin, Ala(2)-MePhe(4)-Gly-ol(5)- HY-P0210 Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol Tyr-D-Ala-Gly-NMePhe-Gly-ol (2S)-2-amino-N-[(1R)-2-[[2-[[(1S)-1-benzyl-2-(2-hydroxyethylamino)-2-oxo-ethyl]-methyl-amino]-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]-3-(4-hydroxyphenyl)propanamide 2-Ala-4-mephe-5-gly-enkephalin AC1Q29AA CHEBI:272 Dagol glyol MolPort-023-276-021 Tyr-D-Ala-Gly-N(CH3)Phe-Gly-ol ZINC53092426 (2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide 83314-80-1 Ala2-MePhe4-Glyol5-Enkephalin CS-0021316 DTXSID30228775 H-Tyr-D-Ala-Gly-N-Me-Phe-Glycinol SCHEMBL725750 Tyr-D-Ala-Gly-N-Methyl-Phe-Gly-ol [tyrosyl-3,5-3H(N)]-D-Ala2-Mephe4-glyol5-enkephalin 117592-80-0 97777-48-5 C-54725 DAGn Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)- L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl- Tyr-D-Ala-Gly-MePhe-Gly(ol) Tyr-D-Ala2-Gly-NMePhe-Gly-ol (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide AKOS024456435 DAMGE GTPL1647 NCGC00167303-01 Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol [3H]DAMGO (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin 91418-78-9 B6621 D-Ala2-MePhe4-Met(0)5-enkephalin-ol Enkephalin, ala(2)-mephe(4)-gly(5)- HPZJMUBDEAMBFI-WTNAPCKOSA-N Tyr-ala-gly-(nme)phe-gly-ol Tyr-D-Ala-Gly-NMe-Phe-Gly-ol [ Show all ]
Inchi Key	HPZJMUBDEAMBFI-WTNAPCKOSA-N
Inchi ID	InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
PubChem CID	5462471
ChEMBL	CHEMBL38874
IUPHAR	1647
BindingDB	21015
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Bmax	9.5 pmol	PMID19113864	ChEMBL
EC50	2.66 nM	PMID19113864	BindingDB,ChEMBL
Ki	11.0 nM	PMID19113864	BindingDB,ChEMBL

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