You can:
Name | 5-hydroxytryptamine receptor 1A |
---|---|
Species | Homo sapiens (Human) |
Gene | HTR1A |
Synonym | 5-HT-1A 5-HT1A serotonin receptor 1A 5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled [ Show all ] |
Disease | Urinary incontinence Generalized anxiety disorder Generalized anxiety disorder; Social phobia Hypertension Hypoactive sexual desire disorder [ Show all ] |
Length | 422 |
Amino acid sequence | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ |
UniProt | P08908 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08908 |
3D structure model | This predicted structure model is from GPCR-EXP P08908. |
BioLiP | N/A |
Therapeutic Target Database | T78709 |
ChEMBL | CHEMBL214 |
IUPHAR | 1 |
DrugBank | BE0000291 |
Name | CHEMBL331037 |
---|---|
Molecular formula | C27H37N5O4S |
IUPAC name | N-[4-[4-[6-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]hexanoyl]piperazin-1-yl]phenyl]methanesulfonamide |
Molecular weight | 527.684 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 3 |
XlogP | 2.4 |
Synonyms | 1-[4-[4-[(Methylsulfonyl)amino]phenyl]piperazin-1-yl]-6-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]-1-hexanone N-[4-(4-{6-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-hexanoyl}-piperazin-1-yl)-phenyl]-methanesulfonamide SCHEMBL6601544 BDBM50033429 L014159 |
Inchi Key | AQUSECISJGGKTA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H37N5O4S/c1-37(34,35)30-22-6-8-23(9-7-22)31-14-16-32(17-15-31)27(33)5-3-2-4-18-36-24-10-11-26-25(19-24)21(12-13-28)20-29-26/h6-11,19-20,29-30H,2-5,12-18,28H2,1H3 |
PubChem CID | 10324625 |
ChEMBL | CHEMBL331037 |
IUPHAR | N/A |
BindingDB | 50033429 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 10.0 nM | PMID7658447 | BindingDB |
Ki | 10.2 nM | PMID7658447 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218