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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	P2Y purinoceptor 14
Species	Homo sapiens (Human)
Gene	P2RY14
Synonym	G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y G protein coupled receptor for UDP-glucose UDP-glucose receptor [ Show all ]
Disease	N/A
Length	338
Amino acid sequence	MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProt	Q15391
Protein Data Bank	N/A
GPCR-HGmod model	Q15391
3D structure model	This predicted structure model is from GPCR-EXP Q15391.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4518
IUPHAR	330
DrugBank	N/A

Ligand

Name	UDP-glucose
Molecular formula	C15H24N2O17P2
IUPAC name	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate
Molecular weight	566.302
Hydrogen bond acceptor	17
Hydrogen bond donor	9
XlogP	-6.3
Synonyms	AC1L1RDS co-waldenase GTPL1783 Uridine 5'-(trihydrogen diphosphate) alpha-D-gucopyranosyl ester Uridine 5'-diphosphoglucose Uridine diphosphoglucose ZINC8215472 C00029 D0DP9H Mono-D-glucosyl ester UNII-V50K1D7P4Y Uridine 5'-(trihydrogen diphosphate), P'-alpha-D-glucopyranosyl ester uridine 5'-[3-alpha-D-glucopyranosyl dihydrogen diphosphate] URIDINE-5'-DIPHOSPHATE-GLUCOSE CHEMBL375951 EINECS 205-121-4 UDP-D-glucose uridine 5''-[3-alpha-D-glucopyranosyl dihydrogen diphosphate] Uridine 5'-diphosphate glucose Uridine diphosphate-glucose URIDINE-5'-MONOPHOSPHATE GLUCOPYRANOSYL-MONOPHOSPHATE ESTER BDBM50209659 Cogalactoisomerase GUD UDPG Uridine 5'-(trihydrogen diphosphate), mono-alpha-d-glucopyranosyl ester Uridine 5'-pyrophosphate glucose ester Uridine pyrophosphate-glucose [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate 5''''-Diphosphoglucose CHEBI:46229 DB01861 SCHEMBL454078 UPG Uridine 5'-(trihydrogen pyrophosphate), mono-alpha-D-glucopyranosyl ester (8CI) Uridine 5-(trihydrogen diphosphate) Uridine-5'-diphospho-glucose disodium salt co-galactoisomerase GLUCOSE-URIDINE-C1,5'-DIPHOSPHATE UDP-Glc Uridine 5'-(alpha-D-glucopyranosyl pyrophosphate) Uridine 5'-diphospho-alpha-D-glucose Uridine diphospho-D-glucose V50K1D7P4Y 133-89-1 BDBM50423218 D07MIE HSCJRCZFDFQWRP-JZMIEXBBSA-N UDPglucose Uridine 5'-(trihydrogen diphosphate), P'-a-D-glucopyranosyl ester (9CI) Uridine 5'-pyrophosphate, alpha-D-glucopyranosyl ester (6CI,7CI) Uridine-5''''-Diphosphoglucose 5'-Diphosphoglucose DTXSID00157902 UDP-alpha-D-Glucose Uridindiphosphoglucose Uridine 5'-(trihydrogen pyrophosphate), mono-D-glucosyl ester URIDINE DIPHOSPHATE GLUCOSE URIDINE-5'-DIPHOSPHOGLUCOSE [ Show all ]
Inchi Key	HSCJRCZFDFQWRP-JZMIEXBBSA-N
Inchi ID	InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
PubChem CID	8629
ChEMBL	CHEMBL375951
IUPHAR	1783
BindingDB	50209659, 50423218
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	261.0 nM	PMID19502066	BindingDB,ChEMBL
EC50	350.0 nM	PMID17407275	BindingDB,ChEMBL
EC50	354.0 nM	PMID17088057	BindingDB,ChEMBL
EC50	400.0 nM	PMID19902968	BindingDB,ChEMBL
EC50	400000.0 nM	PMID25868749	BindingDB,ChEMBL
IC50	79.4328 nM	PMID19339661	IUPHAR

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