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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Mu-type opioid receptor
Species	Mus musculus (Mouse)
Gene	Oprm1
Synonym	opioid receptor, mu 1 opioid receptor OP3 Mu receptor MOR-1 MOPr MOP M-OR-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P42866
Protein Data Bank	4dkl, 5c1m, 6dde, 6ddf
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4dkl.
BioLiP	BL0416752, BL0416751, BL0321492, BL0224753, BL0224754, BL0224755,BL0224756, BL0321491
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2858
IUPHAR	319
DrugBank	N/A

Ligand

Name	CHEMBL316172
Molecular formula	C18H21NO3S
IUPAC name	2-benzyl-N-[(4-hydroxy-3-methoxyphenyl)methyl]-3-sulfanylpropanamide
Molecular weight	331.43
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	2.9
Synonyms	N-(4-Hydroxy-3-methoxybenzyl)-2-benzyl-3-mercaptopropionamide SCHEMBL7300992 BDBM50017738 N-(4-Hydroxy-3-methoxy-benzyl)-2-mercaptomethyl-3-phenyl-propionamide
Inchi Key	ARCUZGVEXOVGTL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H21NO3S/c1-22-17-10-14(7-8-16(17)20)11-19-18(21)15(12-23)9-13-5-3-2-4-6-13/h2-8,10,15,20,23H,9,11-12H2,1H3,(H,19,21)
PubChem CID	14557750
ChEMBL	CHEMBL316172
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	30.0 %	PMID2585440	ChEMBL

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