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GPCR

NamePlatelet-activating factor receptor
SpeciesMus musculus (Mouse)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProtQ62035
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3993
IUPHAR334
DrugBankN/A

Ligand

NameCHEMBL116198
Molecular formulaC22H15Cl2N5O
IUPAC name7,8-dichloro-2-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-3,4-dihydro-1,4-benzodiazepin-5-one
Molecular weight436.296
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.2
Synonyms7,8-Dichloro-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-3,4-dihydro-benzo[e][1,4]diazepin-5-one
2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-7,8-dichloro-3,4-dihydro-5H-1,4-benzodiazepin-5-one
BDBM50033217
SCHEMBL9695814
Inchi KeyHTGJLPLFDGFCBG-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H15Cl2N5O/c1-12-27-20-10-25-7-6-21(20)29(12)14-4-2-13(3-5-14)19-11-26-22(30)15-8-16(23)17(24)9-18(15)28-19/h2-10H,11H2,1H3,(H,26,30)
PubChem CID10094543
ChEMBLCHEMBL116198
IUPHARN/A
BindingDB50033217
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED500.2 mg.kg-1PMID7658438ChEMBL

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