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Name | Adrenocorticotropic hormone receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | MC2R |
Synonym | Melanocortin receptor 2 melanocortin 2 receptor (adrenocorticotropic hormone) melanocortin 2 receptor MC2-R MC2 receptor [ Show all ] |
Disease | N/A |
Length | 297 |
Amino acid sequence | MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW |
UniProt | Q01718 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q01718 |
3D structure model | This predicted structure model is from GPCR-EXP Q01718. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1965 |
IUPHAR | N/A |
DrugBank | BE0000848 |
Name | RY-764 |
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Molecular formula | C34H51FN4O3 |
IUPAC name | (1R,4S,6R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide |
Molecular weight | 582.805 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 5.4 |
Synonyms | Anti-obesity therapy, Merck &Co Melanocortin agonists (obesity/erectile dysfunction), Merck & Co (1R,4S,6R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-7-methyl-7-azabicyclo[2.2.2]octane-6-carboxamide CHEMBL364346 MC4 receptor agonists (obesity) [ Show all ] |
Inchi Key | ARFBDECCXOFCBN-HOLBEBDISA-N |
Inchi ID | InChI=1S/C34H51FN4O3/c1-33(2,3)37-32(42)34(25-8-6-5-7-9-25)16-18-39(19-17-34)31(41)28(21-23-10-13-26(35)14-11-23)36-30(40)27-20-24-12-15-29(27)38(4)22-24/h10-11,13-14,24-25,27-29H,5-9,12,15-22H2,1-4H3,(H,36,40)(H,37,42)/t24-,27+,28+,29+/m0/s1 |
PubChem CID | 6918851 |
ChEMBL | CHEMBL364346 |
IUPHAR | 1337 |
BindingDB | 50169442 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activation | 2.0 % | PMID15982875 | ChEMBL |
IC50 | <10000.0 nM | PMID15982875 | BindingDB,ChEMBL |
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