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Name | Histamine H1 receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | HRH1 |
Synonym | HH1R H1R Hisr H1 receptor |
Disease | Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder [ Show all ] |
Length | 487 |
Amino acid sequence | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS |
UniProt | P35367 |
Protein Data Bank | 3rze |
GPCR-HGmod model | P35367 |
3D structure model | This structure is from PDB ID 3rze. |
BioLiP | BL0202178, BL0202179, BL0202180 |
Therapeutic Target Database | T77913 |
ChEMBL | CHEMBL231 |
IUPHAR | 262 |
DrugBank | BE0000442 |
Name | JNJ-7777120 |
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Molecular formula | C14H16ClN3O |
IUPAC name | (5-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone |
Molecular weight | 277.752 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 2.3 |
Synonyms | 2490AH BC252565 D0E9SR HY-13508 MCULE-4664243664 [ Show all ] |
Inchi Key | HUQJRYMLJBBEDO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3 |
PubChem CID | 4908365 |
ChEMBL | CHEMBL129198 |
IUPHAR | 1279, 1278 |
BindingDB | 22566 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | <10000.0 nM | PMID14722321 | BindingDB |
Ki | 977.0 nM | PMID18983139 | BindingDB |
Ki | 977.24 nM | PMID18983139 | ChEMBL |
Ki | 46773.5 nM | PMID21944853 | BindingDB,ChEMBL |
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