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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL594998
Molecular formulaC14H12ClFN2OS
IUPAC name(2S)-2-(4-chlorophenyl)-2-cyclopropyl-N-(5-fluoro-1,3-thiazol-2-yl)acetamide
Molecular weight310.771
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.3
SynonymsBDBM50305922
(S)-2-(4-chlorophenyl)-2-cyclopropyl-N-(5-fluorothiazol-2-yl)acetamide
Inchi KeyHVWACKKELLLKEV-LBPRGKRZSA-N
Inchi IDInChI=1S/C14H12ClFN2OS/c15-10-5-3-9(4-6-10)12(8-1-2-8)13(19)18-14-17-7-11(16)20-14/h3-8,12H,1-2H2,(H,17,18,19)/t12-/m0/s1
PubChem CID46226336
ChEMBLCHEMBL594998
IUPHARN/A
BindingDB50305922
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy103.0 %PMID20005104ChEMBL
IC501200.0 nMPMID20005104BindingDB,ChEMBL

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