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GPCR

NameGrowth hormone-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneGhrhr
SynonymGhrfr
GHRH receptor
GRF receptor
GRFR
Growth hormone-releasing factor receptor
DiseaseN/A for non-human GPCRs
Length464
Amino acid sequenceMDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProtQ02644
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3709
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1793923
Molecular formulaC150H248N44O42
IUPAC name(3R)-4-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2R)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S,3S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
Molecular weight3339.9
Hydrogen bond acceptor48
Hydrogen bond donor49
XlogP-12.6
SynonymsN/A
Inchi KeyARMNUTFYUKKHFM-QGWRPWCLSA-N
Inchi IDInChI=1S/C150H248N44O42/c1-21-77(14)116(191-123(212)82(19)169-132(221)104(66-113(205)206)178-122(211)80(17)168-124(213)89(153)62-85-41-45-87(199)46-42-85)144(233)185-102(63-84-34-25-24-26-35-84)138(227)194-119(83(20)198)147(236)186-103(65-111(156)203)137(226)188-107(70-196)142(231)182-101(64-86-43-47-88(200)48-44-86)136(225)176-94(40-33-57-166-150(162)163)127(216)175-92(37-28-30-54-152)131(220)190-115(76(12)13)143(232)184-97(58-72(4)5)125(214)167-68-112(204)171-95(49-51-109(154)201)129(218)180-100(61-75(10)11)135(224)187-106(69-195)140(229)170-81(18)121(210)173-93(39-32-56-165-149(160)161)126(215)174-91(36-27-29-53-151)128(217)179-99(60-74(8)9)134(223)181-98(59-73(6)7)133(222)177-96(50-52-110(155)202)130(219)183-105(67-114(207)208)139(228)192-118(79(16)23-3)146(235)193-117(78(15)22-2)145(234)189-108(71-197)141(230)172-90(120(157)209)38-31-55-164-148(158)159/h24-26,34-35,41-48,72-83,89-108,115-119,195-200H,21-23,27-33,36-40,49-71,151-153H2,1-20H3,(H2,154,201)(H2,155,202)(H2,156,203)(H2,157,209)(H,167,214)(H,168,213)(H,169,221)(H,170,229)(H,171,204)(H,172,230)(H,173,210)(H,174,215)(H,175,216)(H,176,225)(H,177,222)(H,178,211)(H,179,217)(H,180,218)(H,181,223)(H,182,231)(H,183,219)(H,184,232)(H,185,233)(H,186,236)(H,187,224)(H,188,226)(H,189,234)(H,190,220)(H,191,212)(H,192,228)(H,193,235)(H,194,227)(H,205,206)(H,207,208)(H4,158,159,164)(H4,160,161,165)(H4,162,163,166)/t77-,78-,79-,80-,81-,82-,83+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103+,104+,105-,106-,107-,108-,115-,116-,117-,118-,119-/m0/s1
PubChem CID56657874
ChEMBLCHEMBL1793923
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Potency3800.0 %PMID3100799ChEMBL

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