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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2005648
Molecular formulaC22H16ClFN2O3
IUPAC name5-chloro-4-(3-fluoro-4-methoxyphenoxy)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
Molecular weight410.829
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.9
SynonymsBDBM50425584
SR-02000001267
SR-02000001267-1
Inchi KeyARNKJISQFPDKSI-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H16ClFN2O3/c1-28-20-10-9-16(11-19(20)24)29-21-18(23)12-25-26(22(21)27)13-15-7-4-6-14-5-2-3-8-17(14)15/h2-12H,13H2,1H3
PubChem CID53234157
ChEMBLCHEMBL2005648
IUPHARN/A
BindingDB50425584
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50360.0 nMPMID23287738, PubChem BioAssay data setBindingDB,ChEMBL

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