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Name | Histamine H1 receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Hrh1 |
Synonym | H1 receptor H1R HH1R Hisr |
Disease | N/A for non-human GPCRs |
Length | 486 |
Amino acid sequence | MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS |
UniProt | P31390 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4701 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL333455 |
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Molecular formula | C18H22FN3S |
IUPAC name | 6-(4-ethylpiperazin-1-yl)-8-fluoro-5,6-dihydropyrrolo[2,1-b][1,3]benzothiazepine |
Molecular weight | 331.453 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 2.9 |
Synonyms | BDBM50108592 SCHEMBL7488822 (+/-)9-(4-Ethyl-piperazin-1-yl)-7-fluoro-9,10-dihydro-4-thia-10a-aza-benzo[f]azulene |
Inchi Key | HXNZZHNYAXGYCA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H22FN3S/c1-2-20-8-10-21(11-9-20)16-13-22-7-3-4-18(22)23-17-6-5-14(19)12-15(16)17/h3-7,12,16H,2,8-11,13H2,1H3 |
PubChem CID | 9949441 |
ChEMBL | CHEMBL333455 |
IUPHAR | N/A |
BindingDB | 50108592 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 4.3 nM | PMID11784139 | BindingDB,ChEMBL |
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