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Name | B1 bradykinin receptor |
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Species | Homo sapiens (Human) |
Gene | BDKRB1 |
Synonym | kinin B1 receptor bradykinin receptor BKR1 BK-1 receptor B1R [ Show all ] |
Disease | Diabetic macular edema Rheumatoid arthritis Pain Osteoarthritis |
Length | 353 |
Amino acid sequence | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN |
UniProt | P46663 |
Protein Data Bank | N/A |
GPCR-HGmod model | P46663 |
3D structure model | This predicted structure model is from GPCR-EXP P46663. |
BioLiP | N/A |
Therapeutic Target Database | T58589 |
ChEMBL | CHEMBL4308 |
IUPHAR | 41 |
DrugBank | BE0005831 |
Name | CHEMBL189123 |
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Molecular formula | C27H25Cl2N5O4S |
IUPAC name | 2-[(2R)-1-(3,4-dichlorophenyl)sulfonyl-3-oxo-2,4-dihydroquinoxalin-2-yl]-N-[2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl]acetamide |
Molecular weight | 586.488 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 3 |
XlogP | 3.1 |
Synonyms | 2-[(R)-1-(3,4-Dichloro-benzenesulfonyl)-3-oxo-1,2,3,4-tetrahydro-quinoxalin-2-yl]-N-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)-phenyl]-ethyl}-acetamide D04WHO (R)-N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenethyl)-2-(1-(3,4-dichlorophenylsulfonyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamide 4-(3,4-Dichlorophenylsulfonyl)-3,4-dihydro-3beta-[2-[[2-[4-(4,5-dihydro-1H-imidazole-2-yl)phenyl]ethyl]amino]-2-oxoethyl]quinoxaline-2(1H)-one GTPL665 [ Show all ] |
Inchi Key | HYJYRDCPGUEYND-XMMPIXPASA-N |
Inchi ID | InChI=1S/C27H25Cl2N5O4S/c28-20-10-9-19(15-21(20)29)39(37,38)34-23-4-2-1-3-22(23)33-27(36)24(34)16-25(35)30-12-11-17-5-7-18(8-6-17)26-31-13-14-32-26/h1-10,15,24H,11-14,16H2,(H,30,35)(H,31,32)(H,33,36)/t24-/m1/s1 |
PubChem CID | 9916412 |
ChEMBL | CHEMBL189123 |
IUPHAR | 665 |
BindingDB | 50156455 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.18 nM | PMID20369879, PMID18674903 | BindingDB,ChEMBL |
Ki | 0.0078 nM | PMID16529929 | BindingDB,ChEMBL |
Ki | 0.03 nM | PMID15546726 | BindingDB,ChEMBL |
Ki | 0.0316228 nM | PMID12812482 | IUPHAR |
Ki | 0.034 nM | PMID16529929, PMID20369879, PMID18674903, PMID22483585 | BindingDB,ChEMBL |
Ki | 0.038 nM | PMID16529929 | BindingDB,ChEMBL |
Ki | 0.049 nM | PMID16529929 | BindingDB,ChEMBL |
Ki | 0.89 nM | PMID16529929 | BindingDB,ChEMBL |
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